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Prescription Medications to Avoid by Dr. Bosworth

Feb 10, 2026
by Self Health Resource Center

 

Prescription Medications to Avoid

In today's world, medications are often seen as the go-to solution for various health concerns. However, as Dr. Annette Bosworth highlights, some commonly prescribed drugs may come with risks that outweigh their benefits, especially when used long-term. Take Metformin, for instance, a medication commonly prescribed for managing Type 2 diabetes. While it can help control blood sugar, its side effects, including gastrointestinal distress and potential long-term impacts on kidney function, are often underestimated. Likewise, GlipiZIDE, another diabetes drug, may cause dangerously low blood sugar levels (hypoglycemia) if not carefully monitored, putting patients at risk of serious health events.

Dr. Bosworth also points to SGLT2 inhibitors, a newer class of medications for diabetes that can lead to dehydration, kidney problems, and even increase the risk of amputations in some patients. Over-the-counter painkillers like Tylenol (acetaminophen), Advil, and Aleve (NSAIDs) might seem harmless, but long-term use can cause liver damage, gastrointestinal issues, or even kidney failure when used excessively. Similarly, Aspirin, often recommended for heart health, poses bleeding risks, especially for those on other medications or with a history of ulcers. Medications like Allopurinol and Febuxostat, prescribed for gout, are not without their own risks, including severe skin reactions and potential cardiovascular problems.

Dr. Bosworth also warns about Beta blockers and ACE inhibitors, which, while commonly used for high blood pressure, can lead to side effects like dizziness, fatigue, or even more serious complications like heart failure. Lastly, Benadryl, an antihistamine commonly used for allergies, has sedative effects that can impair cognitive function, especially in older adults, and its long-term use is linked to memory issues. These medications, while helpful in certain situations, should not be used without careful consideration of their risks, and patients are encouraged to seek alternatives or lifestyle changes when possible. Dr. Bosworth’s message is clear: understanding the potential harm of common prescriptions is just as important as understanding their benefits.

List of the worst OTC Drugs and prescriptions: 

  • Metformin
  • GlipiZIDE
  • SGLT2s
  • Tylenol
  • Advil and Aleve
  • Aspirin
  • Allopurinol and Febuxostat
  • Beta blocker and Ace Inhibitor
  • Benadryl
  • Xanax and Ambien
  • OxyContin and Gabapentin
  • Premarin
  • Estradiol
  • Prempro
  • Micronized Progesterone
  • Finasteride
  • Ozempic and Mounjaro
  • Prilosec and Statin
  • Zetia
  • Repatha and Prozac
  • Prednisone (steroids)
  • Thyroid Medication, ADHD medications, Testosterone

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