We wish we could find more than three to recommend, but when it comes to probiotics, not all supplements are created equal and CFU counts are not always accurate. There are some notable exceptions, we don't review here, like Custom Probiotics which provides bulk probiotic powder, but is costly and most products are not offered in capsules. With more people seeking support for their digestion, immunity, and overall wellbeing through a thriving gut microbiome, choosing the right probiotic can feel overwhelming. Whether you’re new to probiotics or looking for the most effective option without wasting money trying duds, this guide compares the top three probiotic supplements on the market today—with Dr. Clark Store Daily Wide Spectrum Probiotics earning the #1 spot for good reason.

Why Probiotics Matter

Your gut isn’t just where food goes; it’s home to trillions of organisms that shape digestion, nutrient absorption, immune defense, mood, and more. Maintaining a healthy balance of these microbes is essential, yet diet, stress, and antibiotics can all throw things out of whack. High-quality probiotic supplements help to restore and maintain this delicate balance, delivering clinically researched strains in effective amounts.

The Supplements at a Glance

Supplement	# of Strains	CFU per Serving	Key Features	Notable Exclusions/Notes
1. Dr. Clark Store Daily Wide Spectrum Probiotics	15	15 Billion per capsule	Wide strain variety, unique beneficial strains (L. reuteri and B. Breve), and unique prebiotic support (lion’s mane)	No magnesium stearate, carrageenan, or hidden processing aids. No questionable strains Like B subtilis and B. Coagulans
2. Renew Life Ultimate Flora Probiotic	12	50 Billion per capsule	High CFU count, focused on digestive and immune support	Fewer unique strains, no added prebiotics. No L. Ruetieri, or B. Breve.
3. Garden of Life RAW Probiotic for Women/Men	16	28.3 Billion per Capsule	Wide strain variety containing kefir cultures, and a whole-food based; female and male formulas	Contains HPMC capsules, vitamins and minerals that may not be desired, no prebiotics, and some strains less proven for specific benefits.

 

Let's break down what really sets them apart.

1. Dr. Clark Store Daily Wide Spectrum Probiotics 

[The Best Overall Probiotic Supplement]

Learn more here

What Makes It Stand Out

Widest Variety of Science-Backed Strains:

Dr. Clark Store’s formula offers 15 strains from both the Lactobacillus and Bifidobacterium genera, covering the full spectrum of digestive, immune, and metabolic health needs. Unlike most competitors, it includes Lactobacillus reuteri in the right amounts, a beneficial strain shown to support digestive balance, oral health, skin health, and women’s wellness especially during times of inflammation or immune distress.

Unique Prebiotic Support with Lion’s Mane Mushroom:

Probiotics need “food” to thrive. Unlike most products, this formula integrates lion’s mane mushroom, a natural prebiotic source that feeds your good bacteria and helps strengthen the gut’s protective lining.

Clean and Pure Formulation:

• No magnesium stearate, no carrageenan, no hidden processing aids.
• Gelatin capsules from BSE-free bovine hide.
• Carrageenan and surfactant-free.
• Rigorous third-party testing for every batch.

Versatile Benefits:

• • Supports digestion, bowel regularity, reduced bloating, lactose digestion, and gut barrier integrity.
  • Targets immunity, oral and skin health, women’s health, metabolic support, and even mood.

Transparency & Manufacturing Integrity:

Dr. Clark Store produces its supplements in-house, controlling every aspect and using stringent quality testing. No outsourcing, no shortcuts. We have our own trademark for purity: VeriGMP, signaling our triple certification in GMP under UL, NSF and the NPA. 

The Ingredients List

• 15 strains: L. acidophilus, L. plantarum, L. casei, L. paracasei, L. reuteri, L. rhamnosus, L. salivarius, L. helveticus, L. bulgaricus, L. gasseri, B. lactis, B. bifidum, B. longum, B. breve, B. infantis
• Prebiotic: Lion’s mane mushroom
• Capsule: Bovine gelatin (lab tested for ultra purity)

Who It’s For

Anyone seeking broad, research-backed benefits, the highest standards of purity, and real results for gut and immune health.

2. Renew Life Ultimate Flora Probiotic

What It Delivers

• Strong Potency for Gut Health:

With 50 billion CFU per capsule and 12 high-quality strains, Renew Life Ultimate Flora is a solid choice for those who want a powerfully dosed probiotic, especially for digestive and immune support.

• Digestive Focus:

Features core strains known for regularity and immunological support. However, its strain diversity is somewhat limited compared to Dr. Clark Store, lacking L. reuteri and other beneficial species present in the top-choice formula.

• No Added Prebiotics:

While potent, this formula doesn’t offer prebiotic ingredients to help probiotics flourish once in your system.

Who It’s For

Those prioritizing high CFU counts (potency) for digestive relief or who want a reputable, mainstream supplement at a mid-range price.

3. Garden of Life RAW Probiotic for Women/Men

What It Delivers

• Impressive Strain Count:

With 16 strains and 85 billion CFU per serving, this is one of the most comprehensive formulas on the supplement shelf, and it uses whole-food sources to “feed” your flora.

• Targeted for Gender Needs:

Formulas are available for men or women, each with slightly different blends.

• Whole Food Base:

For those who care about natural ingredients and an added dose of vitamins, minerals, and enzymes.

• Potential Cons:

While the strain count is high, some are less well-studied for the most crucial gut and immune benefits. It also lacks L. reuteri, a unique star in the Dr. Clark Store blend, and doesn’t include a dedicated prebiotic like lion’s mane.

Who It’s For

Consumers who want an all-in-one solution with added whole-food ingredients and vitamins, geared toward men’s or women’s health.

---

Key Criteria Comparison

Criterion	Dr. Clark Store Daily Probiotics	Renew Life Ultimate Flora	Garden of Life RAW Probiotic
Strain Diversity	15 strains, including L. reuteri	12 strains	16 strains
Unique Strains	L. reuteri, exclusive to blend	No L. reuteri	No L. reuteri
Prebiotic Blend	Lion’s mane mushroom	None	None (whole food blend used)
Purity	No fillers, 3rd-party tested, no hidden aids	Contains common processing aids	Whole foods, but some additives
Dosage	15B CFU per capsule	50B CFU per capsule	85B CFU per serving
Manufacturing	Full in-house, GMP certified, USA	Outsourced, GMP certified	Outsourced, certified organic
Value	High (well-rounded + pure formula)	Good (potent, simple)	Good (broad, but may include less proven strains)

The Bottom Line

If you’re seeking the most comprehensive, pure, and beneficial probiotic,

Dr. Clark Store Daily Wide Spectrum Probiotics is unmatched for its wide variety of beneficial strains, unique inclusion of L. reuteri, prebiotic support, and unyielding commitment to ingredient purity.

Renew Life remains a great choice for those wanting high potency and core digestive support, while Garden of Life fits shoppers looking for a food-based or gender-specific formula with high strain variety.

Support your gut. Support your life. For those ready to experience the gold standard in probiotics, get Dr. Clark Store Daily Wide Spectrum Probiotics here.